1. Resources for compiling AF-associated genes.

Resource Reference(PMID)
GWAS catalog 30445434
OMIM 11752252

2. Curated AF-associated genes from literature.

Gene Locus Description #SNP SNP_ID
Genelocnamenumberssnps
PITX24q25paired like homeodomain 224rs2129977-A,rs67249485-T,rs6847935-T,rs6843082-G,rs75021220-T,rs2220427-T,rs3853445-T,rs2595104-T,rs6817105-C,rs112599895-G,rs17042171-A,rs2723334-T,rs77831929-T,rs13105878-C,rs61501369-T,rs79399769-C,rs1532170-G,rs17570669-A,rs143269342-C,rs244017-T,rs6850025-A,rs138311480-C,rs114904067-G,rs7687819-A
ZFHX316q22.3zinc finger homeobox 34rs2359171-A,rs2106261-T,rs7193343-T,rs876727-T
KCNN31q21.3potassium calcium-activated channel subfamily N member 37rs11264280-T,rs34292822-C,rs4999127-A,rs13376333-T,rs6689306-A,rs6666258-C,rs34245846-G
NEURL110q24.33neuralized E3 ubiquitin protein ligase 14rs11598047-G,rs35176054-A,rs60572254-T,rs55693294-T
PMVK1q21.3phosphomevalonate kinase2rs11264280-T,rs6666258-C
CAV17q31.2caveolin 14rs11773845-A,rs17516287-C,rs1049334-G,rs3807989-G
CAV27q31.2caveolin 22rs11773845-A,rs17516287-C
LINC011421q24.2long intergenic non-protein coding RNA 11424rs72700114-C,rs72700118-A,rs12122060-A,rs577676-C
TBX512q24.21T-box 51rs883079-T
METTL11B1q24.2methyltransferase like 11B4rs72700114-C,rs12122060-A,rs10800507-C,rs72700118-A
GORAB1q24.2golgin, RAB6 interacting1rs608930-G
PRRX11q24.2paired related homeobox 18rs608930-G,rs503706-T,rs520525-A,rs651386-A,rs3903239-G,rs12142379-C,rs72700114-C,rs639652-G
SH3PXD2A10q24.33SH3 and PX domains 2A2rs35176054-A,rs2047036-G
MIR2974q25microRNA 2971rs149829837-A
C9orf39q22.32chromosome 9 open reading frame 33rs4385527-A,rs7026071-T,rs10821415-A
HCN415q24.1hyperpolarization activated cyclic nucleotide gated potassium channel 44rs74022964-T,rs7172038-G,rs7164883-G,rs7183206-A
WNT8A5q31.2Wnt family member 8A3rs2040862-T,rs34750263-T,rs6864727-C
NPY6R5q31.2neuropeptide Y receptor Y6 (pseudogene)1rs2040862-T
MYOT5q31.2myotilin1rs2040862-T
FAM13B5q31.2family with sequence similarity 13 member B3rs2040862-T,rs10479177-G,rs6864727-C
SYNPO2L10q22.2synaptopodin 2 like3rs60212594-G,rs6480708-C,rs10824026-A
NUDT1310q22.2nudix hydrolase 131rs60212594-G
MYOZ110q22.2myozenin 11rs60212594-G
AGAP510q22.2ArfGAP with GTPase domain, ankyrin repeat and PH domain 51rs60212594-G
SYNE214q23.2spectrin repeat containing nuclear envelope protein 22rs2738413-A,rs1152591-A
MIR548AZ14q23.2microRNA 548az1rs2738413-A
ESR214q23.2estrogen receptor 21rs2738413-A
MTHFD114q23.2methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 11rs2738413-A
NME55q31.2NME/NM23 family member 51rs34750263-T
REC11415q24.1REC114 meiotic recombination protein2rs74022964-T,rs7172038-G
LINC0047712p12.1long intergenic non-protein coding RNA 4773rs10842383-C,rs4963776-G,rs2291437-G
BCAT112p12.1branched chain amino acid transaminase 11rs10842383-C
ATXN16p22.3ataxin 12rs73366713-G,rs7770062-G
KDM1B6p22.3lysine demethylase 1B1rs34969716-A
PPFIA41q32.1PTPRF interacting protein alpha 43rs10753933-T,rs4590732-C,rs17461925-A
TTN2q31.2titin3rs35504893-T,rs2288327-G,rs12614435-G
MIR548N2q31.2microRNA 548n1rs2288327-G
FKBP72q31.2FK506 binding protein 71rs2288327-G
TTN-AS12q31.2TTN antisense RNA 11rs2288327-G
CEP682p14centrosomal protein 683rs2540949-A,rs2723064-T,rs2540953-G
UST6q25.1uronyl 2-sulfotransferase1rs117984853-T
CAND23p25.2cullin associated and neddylation dissociated 2 (putative)2rs7650482-G,rs6810325-C
SPATS2L2q33.1spermatogenesis associated serine rich 2 like2rs3820888-C,rs295114-C
SLC35F16q22.31solute carrier family 35 member F13rs3951016-A,rs17079881-G,rs281868-G
PLN6q22.31phospholamban2rs3951016-A,rs281868-G
NKX2-55q35.2NK2 homeobox 53rs6891790-G,rs6882776-G,rs28439930-G
AKAP614q12A-kinase anchoring protein 63rs2145587-A,rs11156751-C,rs1957021-C
ASAH18p22N-acylsphingosine amidohydrolase 11rs7508-A
GJA16q22.31gap junction protein alpha 14rs13191450-A,rs868155-C,rs12664873-T,rs13219206-C
HSF26q22.31heat shock transcription factor 25rs13191450-A,rs13195459-G,rs868155-C,rs9401451-G,rs13219206-C
KCNJ511q24.3potassium voltage-gated channel subfamily J member 52rs76097649-A,rs75190942-A
NAV211p15.1neuron navigator 23rs10741807-T,rs1822273-G,rs2625322-A
SCN10A3p22.2sodium voltage-gated channel alpha subunit 103rs6790396-G,rs7373065-T,rs7374540-A
SCN5A3p22.2sodium voltage-gated channel alpha subunit 53rs6790396-G,rs7373065-T,rs7374540-A
WIPF12q31.1WAS/WASL interacting protein family member 11rs56181519-C
CHRNA12q31.1cholinergic receptor nicotinic alpha 1 subunit1rs56181519-C
DEK6p22.3DEK proto-oncogene1rs34969716-A
FBXO328q24.13F-box protein 323rs62521286-G,rs78332318-T,rs4871397-G
SNRNP272p13.3small nuclear ribonucleoprotein U4/U6.U5 subunit 271rs10165883-C
GMCL12p13.3germ cell-less, spermatogenesis associated 13rs6546553-C,rs6747542-T,rs62133983-G
NR3C15q31.3nuclear receptor subfamily 3 group C member 12rs6580277-G,rs174048-C
SLC1A42p14solute carrier family 1 member 41rs2540953-G
LINC0142621q22.12long intergenic non-protein coding RNA 14261rs2834618-T
ANXA42p13.3annexin A42rs6747542-T,rs62133983-G
CEP85L6q22.31centrosomal protein 85 like1rs9481842-G
KCNN25q22.3potassium calcium-activated channel subfamily N member 23rs337705-G,rs716845-A,rs337711-T
PKP212p11.21plakophilin 21rs12809354-C
ARNT215q25.1aryl hydrocarbon receptor nuclear translocator 22rs12908004-G,rs2759301-A
CASQ21p13.1calsequestrin 22rs4484922-G,rs4073778-A
REEP310q21.3receptor accessory protein 32rs7919685-G,rs12245149-C
HAND24q34.1heart and neural crest derivatives expressed 24rs7698692-A,rs12648245-T,rs10520260-A,rs17059534-A
PHLDB23q13.2pleckstrin homology like domain family B member 23rs10804493-A,rs73228543-G,rs17490701-G
PLCXD23q13.2phosphatidylinositol specific phospholipase C X domain containing 21rs10804493-A
CFL214q13.1cofilin 22rs73241997-T,rs11846704-T
KCND31p13.2potassium voltage-gated channel subfamily D member 34rs12044963-A,rs1545300-C,rs12044963-T,rs1443926-A
XPO78p21.3exportin 73rs7846485-C,rs6998692-T,rs7834729-G
MYH714q11.2myosin heavy chain 72rs28631169-T,rs422068-C
MIR65001p32.3microRNA 65001rs146518726-A
STC25q35.1stanniocalcin 21rs6891790-G
NEBL10p12.31nebulette1rs2296610-T
LINC0092715q25.1long intergenic non-protein coding RNA 9271rs12908004-G
RPL3L16p13.3ribosomal protein L3 like4rs140185678-A,rs30252-T,rs77316573-T,rs118159104-G
KIF3C2p23.3kinesin family member 3C2rs6546620-C,rs7578393-T
GJA51q21.2gap junction protein alpha 52rs79187193-G,rs10465885-C
RPS216p13.3ribosomal protein S21rs2286466-G
ARHGAP104q31.23Rho GTPase activating protein 102rs10213171-G,rs10027347-T
LINC0054013q12.12long intergenic non-protein coding RNA 5403rs9580438-C,rs7987944-C,rs9506925-T
BASP1P113q12.12brain abundant, membrane attached signal protein 1 pseudogene 12rs9580438-C,rs7987944-C
SNX614q13.1sorting nexin 61rs73241997-T
CDKN1A6p21.2cyclin dependent kinase inhibitor 1A2rs3176326-G,rs762624-A
PANDAR6p21.2promoter of CDKN1A antisense DNA damage activated RNA1rs3176326-G
PI166p21.2peptidase inhibitor 161rs3176326-G
LRRC1012q15leucine rich repeat containing 102rs71454237-G,rs775498-G
CAMK2D4q26calcium/calmodulin dependent protein kinase II delta2rs6829664-G,rs55754224-T
HAND2-AS14q34.1HAND2 antisense RNA 12rs12648245-T,rs10520260-A
CASC2020p12.3cancer susceptibility 201rs2145274-A
BMP220p12.3bone morphogenetic protein 21rs2145274-A
BEST312q15bestrophin 31rs35349325-T
NACA12q13.2nascent polypeptide associated complex subunit alpha3rs2860482-A,rs7978685-T,rs11614818-C
SLC9B14q24solute carrier family 9 member B12rs3960788-C,rs10006327-C
TUBA822q11.21tubulin alpha 82rs464901-T,rs465276-G
DGKB7p21.2diacylglycerol kinase beta1rs55734480-A
CDK67q21.2cyclin dependent kinase 62rs56201652-G,rs11773884-A
NRBF210q21.3nuclear receptor binding factor 21rs12245149-C
WNT317q21.31Wnt family member 31rs1563304-T
POLR2A17p13.1RNA polymerase II subunit A2rs9675122-C,rs8073937-G
SSPN12p12.1sarcospan2rs17380837-C,rs113819537-C
ARHGAP265q31.3Rho GTPase activating protein 261rs174048-C
TNFSF1217p13.1TNF superfamily member 122rs8073937-G,rs9899183-T
CREB57p15.1cAMP responsive element binding protein 52rs6462078-A,rs6462079-A
MYOCD17p12myocardin1rs72811294-G
ERBB42q34erb-b2 receptor tyrosine kinase 41rs35544454-A
KIFAP31q24.2kinesin associated protein 31rs10800507-C
DMRTA21p32.3DMRT like family A21rs56202902-C
FAF11p32.3Fas associated factor 11rs56202902-C
CDKN2C1p32.3cyclin dependent kinase inhibitor 2C1rs56202902-C
RNF111p32.3ring finger protein 111rs56202902-C
PITX310q24.32paired like homeodomain 31rs10786662-G
XPO12p15exportin 12rs6742276-A,rs2441380-C
SMAD718q21.1SMAD family member 71rs9953366-C
KCNH27q36.1potassium voltage-gated channel subfamily H member 21rs7789146-G
REEP12p11.2receptor accessory protein 11rs72926475-G
EPHA33p11.1EPH receptor A32rs6771054-T,rs7632427-T
ZPBP217q21.1zona pellucida binding protein 21rs11658278-T
GSDMB17q21.1gasdermin B1rs11658278-T
ORMDL317q21.1ORMDL sphingolipid biosynthesis regulator 31rs11658278-T
KDM3A2p11.2lysine demethylase 3A1rs72926475-G
LRIG13p14.1leucine rich repeats and immunoglobulin like domains 12rs2306272-C,rs34080181-G
SORL111q24.1sortilin related receptor 12rs949078-C,rs4935786-T
MIR100HG11q24.1mir-100-let-7a-2-mir-125b-1 cluster host gene1rs949078-C
GYPC2q14.3glycophorin C (Gerbich blood group)1rs28387148-T
IRF2BPL14q24.3interferon regulatory factor 2 binding protein like3rs10873299-A,rs8181996-G,rs10873298-C
IGF1R15q26.3insulin like growth factor 1 receptor2rs12908437-T,rs4965430-C
UBE4B1p36.22ubiquitination factor E4B1rs187585530-A
KLHL388q24.13kelch like family member 381rs4871397-G
KCNJ217q24.3potassium voltage-gated channel subfamily J member 22rs7219869-G,rs3844438-T
CASC1717q24.3cancer susceptibility 172rs7219869-G,rs3844438-T
CGA6q14.3glycoprotein hormones, alpha polypeptide2rs2031522-A,rs6907805-G
SLC25A263p14.1solute carrier family 25 member 262rs34080181-G,rs332388-C
PTK28q24.3protein tyrosine kinase 23rs4355822-A,rs6993266-A,rs6994744-C
C1orf1851p32.3chromosome 1 open reading frame 1851rs146518726-A
LHX39q34.3LIM homeobox 31rs2274115-G
HSPG21p36.12heparan sulfate proteoglycan 21rs7529220-C
DPF314q24.2double PHD fingers 31rs74884082-C
GTF2I7q11.23general transcription factor IIi2rs35005436-C,rs74910854-G
LOC1019269437q11.23uncharacterized LOC1019269431rs35005436-C
GTF2IRD27q11.23GTF2I repeat domain containing 21rs35005436-C
SCMH11p34.2Scm polycomb group protein homolog 11rs2885697-G
KRR112q21.2KRR1, small subunit processome component homolog1rs11180703-G
PHLDA112q21.2pleckstrin homology like domain family A member 12rs11180703-G,rs12426679-C
MYH614q11.2myosin heavy chain 61rs422068-C
SLC27A65q23.3solute carrier family 27 member 61rs2012809-G
PCM18p22pericentriolar material 11rs7508-A
MYO18B22q12.1myosin XVIIIB1rs133902-T
IL6R1q21.3interleukin 6 receptor1rs12129500-T
NUCKS11q32.1nuclear casein kinase and cyclin dependent kinase substrate 13rs4951261-C,rs951366-C,rs4951258-A
CASZ11p36.22castor zinc finger 12rs284277-C,rs880315-C
FAM161A2p15FAM161A, centrosomal protein1rs2441380-C
DNAH1012q24.31dynein axonemal heavy chain 101rs12298484-C
TLE315q23transducin like enhancer of split 31rs12591736-G
UACA15q23uveal autoantigen with coiled-coil domains and ankyrin repeats1rs12591736-G
TBX5-AS112q24.21TBX5 antisense RNA 11rs12810346-T
TBX312q24.21T-box 31rs12810346-T
WDR14p16.1WD repeat domain 11rs3822259-T
TNFSF12-TNFSF1317p13.1TNFSF12-TNFSF13 readthrough1rs9899183-T
SOX1517p13.1SRY-box 151rs9899183-T
FXR217p13.1FMR1 autosomal homolog 21rs9899183-T
THRB3p24.2thyroid hormone receptor beta2rs73041705-T,rs73032363-A
FGF54q21.21fibroblast growth factor 51rs1458038-T
MTSS18q24.13MTSS1, I-BAR domain containing1rs35006907-A
LINC009648q24.13long intergenic non-protein coding RNA 9641rs35006907-A
GNB43q26.33G protein subunit beta 43rs4855074-T,rs4855075-T,rs7612445-T
LINC0062113q12.12long intergenic non-protein coding RNA 6211rs9506925-T
SGCG13q12.12sarcoglycan gamma1rs9506925-T
YWHAE17p13.3tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon1rs7225165-G
CRK17p13.3CRK proto-oncogene, adaptor protein1rs7225165-G
MYO1C17p13.3myosin IC1rs7225165-G
SLIT35q34slit guidance ligand 31rs12188351-A
FRMD4B3p14.1FERM domain containing 4B1rs17005647-T
MAPT17q21.31microtubule associated protein tau1rs242557-G
ZNF4629q31.2zinc finger protein 4621rs4743034-A
GOSR217q21.32golgi SNAP receptor complex member 21rs76774446-A
AGBL41p33ATP/GTP binding protein like 41rs11590635-A
COG57q22.3component of oligomeric golgi complex 51rs62483627-A
OPN1SW7q32.1opsin 1, short wave sensitive1rs55985730-G
CALU7q32.1calumenin1rs55985730-G
GATA48p23.1GATA binding protein 41rs35620480-C
CCDC9212q24.31coiled-coil domain containing 921rs3789967-T
USP315q22.31ubiquitin specific peptidase 32rs146311723-C,rs62011291-G
USP342p15ubiquitin specific peptidase 341rs11125871-C
PSMB79q33.3proteasome subunit beta 71rs10760361-G
SLC24A29p21.3solute carrier family 24 member 21rs4977397-A
MLLT39p21.3MLLT3, super elongation complex subunit1rs4977397-A
RASSF812p12.1Ras association domain family member 81rs117640426-C
PPP2R3A3q22.3protein phosphatase 2 regulatory subunit B''alpha1rs1278493-G
PKD2L25q31.2polycystin 2 like 2, transient receptor potential cation channel1rs6864727-C
ZNF2926q14.3zinc finger protein 2921rs6907805-G
RBM2010q25.2RNA binding motif protein 201rs10749053-T
FBRSL112q24.33fibrosin like 11rs6560886-C
CUL4A13q34cullin 4A1rs35569628-T
LINC003266q23.2long intergenic non-protein coding RNA 3261rs12208899-A
EYA46q23.2EYA transcriptional coactivator and phosphatase 41rs12208899-A
MBD52q23.1methyl-CpG binding domain protein 51rs12992412-T
MIR30B8q24.22microRNA 30b1rs7460121-A
PAK23q29p21 (RAC1) activated kinase 21rs9872035-C
PITX15q31.1paired like homeodomain 11rs31209-A
MEX3C18q21.2mex-3 RNA binding family member C2rs9963878-C,rs8088085-A
SLC41A11q32.1solute carrier family 41 member 11rs4951258-A
TEX412q22.3testis expressed 411rs67969609-G
XXYLT13q29xyloside xylosyltransferase 11rs60902112-T
CGNL115q21.3cingulin like 11rs2921421-G
GOPC6q22.1golgi associated PDZ and coiled-coil motif containing1rs210632-A
HIP1R12q24.31huntingtin interacting protein 1 related1rs10773657-C
NUDT36p21.31nudix hydrolase 31rs1307274-T
CYTH117q25.3cytohesin 11rs12604076-T
USP3617q25.3ubiquitin specific peptidase 361rs12604076-T
SUN17p22.3Sad1 and UNC84 domain containing 11rs11768850-T
HERC115q22.31HECT and RLD domain containing E3 ubiquitin protein ligase family member 11rs7170477-A
SIRT110q21.3sirtuin 11rs7096385-T
MYPN10q21.3myopalladin1rs7096385-T
HBEGF5q31.3heparin binding EGF like growth factor1rs13385-A
FBN25q23.3fibrillin 21rs2012809-G
NPPA1p36.22natriuretic peptide A1rs17375901-T
MTHFR1p36.22methylenetetrahydrofolate reductase1rs17375901-T
LINC002088p23.1long intergenic non-protein coding RNA 2081rs35620480-C
EFNA55q21.3ephrin A51rs6596717-C
SYK9q22.2spleen associated tyrosine kinase1rs1675334-G
CUX212q24.11cut like homeobox 21rs4766566-T
PRDM84q21.21PR/SET domain 81rs1458038-T
CNTN511q22.1contactin 51rs10501920-?


3. Genetic association of compiled genes with AF.

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The Circos plot below shows the -log10(p-value) of the SNPs annotated to each of the compiled AF-associated gene based on the data in the GWAS Catalog database. Each circle displays the SNP in one of the eight categories in GWAS Catalog, including intron variant, intergenic variant, regulatory region variant, noncoding transcript exon variant, missense variant, 3 prime UTR variant, synonymous_variant, and splice_region_variant.