You queried the gene APP in brain:

Symbol Synonyms map_location description
APP AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 21q21.3 amyloid beta precursor protein
  • Local network

The network contains the top 25 neighbors, and 178 gene pairs are found in total.

Download gene network data

  • Network analysis
  • Gene analysis
  • Local Network
  • Gene Ontology Enrichment
  • Disease/traits enrichment

The weight between APP and the top connected 25 genes.
Gene A Gene B Weight


Gene Ontology Enrichment Analysis (Biological Process Terms)

Enrichment Results for APP and its neighbors in brain network

GO IDGO nameFDR
GO:0070997neuron death3.18e-25
GO:0007626locomotory behavior4.63e-25
GO:1901214regulation of neuron death8.00e-24
GO:0008344adult locomotory behavior1.27e-23
GO:0048638regulation of developmental growth3.21e-22
GO:0030534adult behavior9.99e-20
GO:0046677response to antibiotic1.49e-19
GO:1901215negative regulation of neuron death4.97e-19
GO:0006979response to oxidative stress4.02e-18
GO:0035264multicellular organism growth4.07e-18
GO:1901652response to peptide7.51e-18
GO:0040014regulation of multicellular organism growth1.47e-17
GO:0051402neuron apoptotic process1.32e-16
GO:0042063gliogenesis2.44e-16
GO:0061564axon development7.96e-16
GO:0043523regulation of neuron apoptotic process2.82e-15
GO:0048872homeostasis of number of cells4.33e-15
GO:0007409axonogenesis2.62e-14
GO:0006816calcium ion transport2.69e-14
GO:0007568aging3.33e-14
GO:1901653cellular response to peptide4.19e-14
GO:0010038response to metal ion7.56e-14
GO:0034599cellular response to oxidative stress7.58e-14
GO:0071900regulation of protein serine/threonine kinase activity8.20e-14
GO:0030099myeloid cell differentiation1.63e-13
GO:0050890cognition1.71e-13
GO:0007611learning or memory1.81e-13
GO:0070588calcium ion transmembrane transport1.90e-13
GO:0034248regulation of cellular amide metabolic process2.39e-13
GO:0000302response to reactive oxygen species3.73e-13
GO:0042110T cell activation4.48e-13
GO:0002521leukocyte differentiation5.15e-13
GO:0032496response to lipopolysaccharide6.18e-13
GO:0070838divalent metal ion transport6.62e-13
GO:0010001glial cell differentiation6.72e-13
GO:0072511divalent inorganic cation transport8.84e-13
GO:2001233regulation of apoptotic signaling pathway1.10e-12
GO:0043524negative regulation of neuron apoptotic process1.21e-12
GO:0006874cellular calcium ion homeostasis1.22e-12
GO:0070371ERK1 and ERK2 cascade1.42e-12
GO:0090066regulation of anatomical structure size2.37e-12
GO:0035690cellular response to drug2.78e-12
GO:0002237response to molecule of bacterial origin3.20e-12
GO:0055074calcium ion homeostasis4.22e-12
GO:0097193intrinsic apoptotic signaling pathway4.77e-12
GO:0042391regulation of membrane potential7.71e-12
GO:0051235maintenance of location9.24e-12
GO:0051403stress-activated MAPK cascade1.08e-11
GO:0034249negative regulation of cellular amide metabolic process1.50e-11
GO:0048511rhythmic process1.57e-11


No enrichment is identified for this network.
  • Tissue-specific analysis
  • Gene Ontology
  • Human phenotype ontology
  • GWAS
  • Drug

Tissue-specific expression distribution of APP.


Gene ontology annotations for the queried gene based on Gene Ontology.

BP: Biological Process, MF: Molecular Function, CC: Cellular Component.
Gene GO_ID GO_term Category Evidence
APPGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingMFIEA
APPGO:0001774microglial cell activationBPIGI
APPGO:0001934positive regulation of protein phosphorylationBPIDA,IGI
APPGO:0001967suckling behaviorBPIEA
APPGO:0002265astrocyte activation involved in immune responseBPIGI
APPGO:0002576platelet degranulationBPTAS
APPGO:0003677DNA bindingMFISS
APPGO:0004867serine-type endopeptidase inhibitor activityMFIDA
APPGO:0005102signaling receptor bindingMFIPI
APPGO:0005515protein bindingMFIPI
APPGO:0005576extracellular regionCCTAS
APPGO:0005615extracellular spaceCCHDA,IDA
APPGO:0005641nuclear envelope lumenCCIDA
APPGO:0005737cytoplasmCCIDA,ISS
APPGO:0005768endosomeCCIDA
APPGO:0005769early endosomeCCISS
APPGO:0005788endoplasmic reticulum lumenCCTAS
APPGO:0005790smooth endoplasmic reticulumCCIEA
APPGO:0005791rough endoplasmic reticulumCCIEA
APPGO:0005794Golgi apparatusCCIDA,ISS
APPGO:0005796Golgi lumenCCTAS
APPGO:0005798Golgi-associated vesicleCCISS
APPGO:0005829cytosolCCTAS
APPGO:0005886plasma membraneCCIDA,TAS
APPGO:0005887integral component of plasma membraneCCTAS
APPGO:0005905clathrin-coated pitCCIEA
APPGO:0005911cell-cell junctionCCIEA
APPGO:0006378mRNA polyadenylationBPISS
APPGO:0006417regulation of translationBPISS
APPGO:0006468protein phosphorylationBPISS
APPGO:0006878cellular copper ion homeostasisBPISS
APPGO:0006897endocytosisBPISS
APPGO:0006979response to oxidative stressBPIEA
APPGO:0007155cell adhesionBPIEA
APPGO:0007176regulation of epidermal growth factor-activated receptor activityBPISS
APPGO:0007186G protein-coupled receptor signaling pathwayBPTAS
APPGO:0007219Notch signaling pathwayBPIEA
APPGO:0007409axonogenesisBPISS
APPGO:0007611learning or memoryBPIGI,IMP,TAS
APPGO:0007612learningBPIMP
APPGO:0007617mating behaviorBPISS
APPGO:0007626locomotory behaviorBPISS
APPGO:0008021synaptic vesicleCCIEA
APPGO:0008088axo-dendritic transportBPISS
APPGO:0008201heparin bindingMFIEA
APPGO:0008203cholesterol metabolic processBPIEA
APPGO:0008285negative regulation of cell population proliferationBPIDA
APPGO:0008344adult locomotory behaviorBPISS
APPGO:0008542visual learningBPISS
APPGO:0009986cell surfaceCCIDA
APPGO:0009987cellular processBPIMP
APPGO:0010288response to lead ionBPIEA
APPGO:0010468regulation of gene expressionBPIGI,IMP
APPGO:0010628positive regulation of gene expressionBPIGI,IMP
APPGO:0010629negative regulation of gene expressionBPIGI
APPGO:0010800positive regulation of peptidyl-threonine phosphorylationBPIMP
APPGO:0010951negative regulation of endopeptidase activityBPIEA
APPGO:0010952positive regulation of peptidase activityBPIEA
APPGO:0010971positive regulation of G2/M transition of mitotic cell cycleBPIEA
APPGO:0014005microglia developmentBPIGI
APPGO:0016021integral component of membraneCCISS
APPGO:0016199axon midline choice point recognitionBPISS
APPGO:0016322neuron remodelingBPISS
APPGO:0016358dendrite developmentBPISS
APPGO:0016504peptidase activator activityMFIEA
APPGO:0019899enzyme bindingMFIPI
APPGO:0030111regulation of Wnt signaling pathwayBPIC
APPGO:0030134COPII-coated ER to Golgi transport vesicleCCIEA
APPGO:0030198extracellular matrix organizationBPISS,TAS
APPGO:0030424axonCCISS
APPGO:0030546signaling receptor activator activityMFIEA
APPGO:0030900forebrain developmentBPIEA
APPGO:0031093platelet alpha granule lumenCCTAS
APPGO:0031175neuron projection developmentBPISS
APPGO:0031594neuromuscular junctionCCIEA
APPGO:0031904endosome lumenCCTAS
APPGO:0032092positive regulation of protein bindingBPIGI
APPGO:0032588trans-Golgi network membraneCCTAS
APPGO:0032722positive regulation of chemokine productionBPIGI
APPGO:0032731positive regulation of interleukin-1 beta productionBPIGI
APPGO:0032755positive regulation of interleukin-6 productionBPIGI
APPGO:0032760positive regulation of tumor necrosis factor productionBPIGI
APPGO:0033138positive regulation of peptidyl-serine phosphorylationBPIMP
APPGO:0035235ionotropic glutamate receptor signaling pathwayBPISS
APPGO:0035253ciliary rootletCCIEA
APPGO:0040014regulation of multicellular organism growthBPISS
APPGO:0042327positive regulation of phosphorylationBPIGI
APPGO:0042802identical protein bindingMFIPI
APPGO:0043197dendritic spineCCIDA
APPGO:0043198dendritic shaftCCIDA
APPGO:0043204perikaryonCCIEA
APPGO:0043235receptor complexCCIDA
APPGO:0043687post-translational protein modificationBPTAS
APPGO:0044267cellular protein metabolic processBPTAS
APPGO:0044304main axonCCIEA
APPGO:0045087innate immune responseBPTAS
APPGO:0045121membrane raftCCIDA
APPGO:0045177apical part of cellCCIEA
APPGO:0045202synapseCCIDA
APPGO:0045665negative regulation of neuron differentiationBPIEA
APPGO:0045821positive regulation of glycolytic processBPIGI
APPGO:0045931positive regulation of mitotic cell cycleBPISS
APPGO:0045944positive regulation of transcription by RNA polymerase IIBPIGI
APPGO:0046330positive regulation of JNK cascadeBPIGI
APPGO:0046914transition metal ion bindingMFIEA
APPGO:0048143astrocyte activationBPIGI
APPGO:0048169regulation of long-term neuronal synaptic plasticityBPIGI
APPGO:0048471perinuclear region of cytoplasmCCIDA
APPGO:0048669collateral sprouting in absence of injuryBPISS
APPGO:0048786presynaptic active zoneCCIEA
APPGO:0050729positive regulation of inflammatory responseBPIMP
APPGO:0050730regulation of peptidyl-tyrosine phosphorylationBPIGI
APPGO:0050803regulation of synapse structure or activityBPISS
APPGO:0050808synapse organizationBPIGI
APPGO:0050885neuromuscular process controlling balanceBPIEA
APPGO:0050890cognitionBPISS
APPGO:0051091positive regulation of DNA-binding transcription factor activityBPIGI
APPGO:0051092positive regulation of NF-kappaB transcription factor activityBPIGI
APPGO:0051124synaptic growth at neuromuscular junctionBPIEA
APPGO:0051233spindle midzoneCCIEA
APPGO:0051247positive regulation of protein metabolic processBPIMP,ISS
APPGO:0051402neuron apoptotic processBPIMP
APPGO:0051425PTB domain bindingMFIPI
APPGO:0051563smooth endoplasmic reticulum calcium ion homeostasisBPIEA
APPGO:0055037recycling endosomeCCISS
APPGO:0070062extracellular exosomeCCHDA
APPGO:0070374positive regulation of ERK1 and ERK2 cascadeBPIGI
APPGO:0070555response to interleukin-1BPISS
APPGO:0070851growth factor receptor bindingMFIEA
APPGO:0071280cellular response to copper ionBPIEA
APPGO:0071287cellular response to manganese ionBPIEA
APPGO:0071320cellular response to cAMPBPIEA
APPGO:0071874cellular response to norepinephrine stimulusBPIEA
APPGO:0090647modulation of age-related behavioral declineBPIGI,IMP,TAS
APPGO:0097449astrocyte projectionCCIEA
APPGO:0098815modulation of excitatory postsynaptic potentialBPIGI
APPGO:0150003regulation of spontaneous synaptic transmissionBPIGI
APPGO:1900272negative regulation of long-term synaptic potentiationBPIGI
APPGO:1900273positive regulation of long-term synaptic potentiationBPIGI
APPGO:1901224positive regulation of NIK/NF-kappaB signalingBPIGI,IMP
APPGO:1904646cellular response to amyloid-betaBPIGI
APPGO:1905598negative regulation of low-density lipoprotein receptor activityBPIGI
APPGO:1905606regulation of presynapse assemblyBPIDA,IMP
APPGO:1905908positive regulation of amyloid fibril formationBPIMP
APPGO:1990000amyloid fibril formationBPIMP
APPGO:1990090cellular response to nerve growth factor stimulusBPIEA
APPGO:1990535neuron projection maintenanceBPIGI
APPGO:1990761growth cone lamellipodiumCCIEA
APPGO:1990812growth cone filopodiumCCIEA
APPGO:2000310regulation of NMDA receptor activityBPTAS
APPGO:2000406positive regulation of T cell migrationBPIMP

Associated human phenotype annotations for the queried gene based on Human Phenotype Ontology(2019).

Gene HPO-ID HPO-Name Disease
APPHP:0000708Behavioral abnormalityCerebral amyloid angiopathy, APP-related
APPHP:0011970Cerebral amyloid angiopathyCerebral amyloid angiopathy, APP-related
APPHP:0002315HeadacheCerebral amyloid angiopathy, APP-related
APPHP:0000726DementiaCerebral amyloid angiopathy, APP-related
APPHP:0001342Cerebral hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0001250SeizureCerebral amyloid angiopathy, APP-related
APPHP:0100613Death in early adulthoodCerebral amyloid angiopathy, APP-related
APPHP:0002514Cerebral calcificationCerebral amyloid angiopathy, APP-related
APPHP:0001297StrokeCerebral amyloid angiopathy, APP-related
APPHP:0000708Behavioral abnormalityCerebral amyloid angiopathy, APP-related
APPHP:0002373Febrile seizure (within the age range of 3 months to 6 years)Cerebral amyloid angiopathy, APP-related
APPHP:0002511Alzheimer diseaseAlzheimer disease
APPHP:0000726DementiaAlzheimer disease
APPHP:0000006Autosomal dominant inheritanceAlzheimer disease
APPHP:0001425HeterogeneousAlzheimer disease
APPHP:0001300ParkinsonismAlzheimer disease
APPHP:0002185Neurofibrillary tanglesAlzheimer disease
APPHP:0410054Decreased level of GABA in serumAlzheimer disease
APPHP:0002423Long-tract signsAlzheimer disease
APPHP:0002076MigraineCerebral amyloid angiopathy, APP-related
APPHP:0001250SeizureCerebral amyloid angiopathy, APP-related
APPHP:0001342Cerebral hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0001297StrokeCerebral amyloid angiopathy, APP-related
APPHP:0000726DementiaCerebral amyloid angiopathy, APP-related
APPHP:0001259ComaCerebral amyloid angiopathy, APP-related
APPHP:0002354Memory impairmentAlzheimer disease, type 14
APPHP:0001249Intellectual disabilityAlzheimer disease, type 14
APPHP:0001300ParkinsonismAlzheimer disease, type 14
APPHP:0002120Cerebral cortical atrophyAlzheimer disease, type 14
APPHP:0030219Semantic dementiaAlzheimer disease, type 14
APPHP:0002463Language impairmentAlzheimer disease, type 14
APPHP:0010526DysgraphiaAlzheimer disease, type 14
APPHP:0001276HypertoniaAlzheimer disease, type 14
APPHP:0001289ConfusionAlzheimer disease, type 14
APPHP:0012433Abnormal social behaviorAlzheimer disease, type 14
APPHP:0001250SeizureAlzheimer disease, type 14
APPHP:0002381AphasiaAlzheimer disease, type 14
APPHP:0000713AgitationAlzheimer disease, type 14
APPHP:0002185Neurofibrillary tanglesAlzheimer disease, type 14
APPHP:0000504Abnormality of visionAlzheimer disease, type 14
APPHP:0003791Deposits immunoreactive to beta-amyloid proteinAlzheimer disease, type 14
APPHP:0010525Finger agnosiaAlzheimer disease, type 14
APPHP:0000657Oculomotor apraxiaAlzheimer disease, type 14
APPHP:0000734DisinhibitionAlzheimer disease, type 14
APPHP:0001336MyoclonusAlzheimer disease, type 14
APPHP:0000738HallucinationsAlzheimer disease, type 14
APPHP:0001251AtaxiaAlzheimer disease, type 14
APPHP:0000726DementiaCerebral amyloid angiopathy, APP-related
APPHP:0002076MigraineCerebral amyloid angiopathy, APP-related
APPHP:0001259ComaCerebral amyloid angiopathy, APP-related
APPHP:0003401ParesthesiaCerebral amyloid angiopathy, APP-related
APPHP:0001249Intellectual disabilityCerebral amyloid angiopathy, APP-related
APPHP:0001342Cerebral hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0000708Behavioral abnormalityCerebral amyloid angiopathy, APP-related
APPHP:0001297StrokeCerebral amyloid angiopathy, APP-related
APPHP:0001263Global developmental delayCerebral amyloid angiopathy, APP-related
APPHP:0004938Tortuous cerebral arteriesCerebral amyloid angiopathy, APP-related
APPHP:0001297StrokeCerebral amyloid angiopathy, APP-related
APPHP:0000006Autosomal dominant inheritanceCerebral amyloid angiopathy, APP-related
APPHP:0011695Cerebellar hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0004968Recurrent cerebral hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0000726DementiaCerebral amyloid angiopathy, APP-related
APPHP:0002637Cerebral ischemiaCerebral amyloid angiopathy, APP-related
APPHP:0011970Cerebral amyloid angiopathyCerebral amyloid angiopathy, APP-related
APPHP:0000726DementiaCerebral amyloid angiopathy, APP-related
APPHP:0001342Cerebral hemorrhageCerebral amyloid angiopathy, APP-related
APPHP:0001288Gait disturbanceCerebral amyloid angiopathy, APP-related
APPHP:0002354Memory impairmentCerebral amyloid angiopathy, APP-related
APPHP:0000708Behavioral abnormalityCerebral amyloid angiopathy, APP-related
APPHP:0001297StrokeCerebral amyloid angiopathy, APP-related
APPHP:0001336MyoclonusCerebral amyloid angiopathy, APP-related
APPHP:0002015DysphagiaCerebral amyloid angiopathy, APP-related

Your queried gene is not associated with any traits/disease in GWAS Catalog.

Associated drugs for the queried gene based on DGIdb (2021-May).

'-': indicating missing value not available in DGIdb.

Gene DrugName Score Type Source
APPBAN24014.16-TTD
APPPonezumab4.16-TTD
APPCHEMBL17430584.16-ChemblInteractions
APPGSK9337764.16-TTD
APPCHEMBL21093004.16-ChemblInteractions
APPCHEMBL21085764.16-ChemblInteractions
APPCHEMBL17430724.16-ChemblInteractions
APPCHEMBL17430044.16-ChemblInteractions
APPCHEMBL38333214.16inhibitorChemblInteractions
APPCHEMBL17430254.16-ChemblInteractions
APPMABT5102A4.16-TdgClinicalTrial
APPSOLANEZUMAB4.16-TdgClinicalTrial
APPSolanezumab4.16-TTD
APPGantenerumab4.16-TTD
APPBAN24014.16-TdgClinicalTrial
APPBAPINEUZUMAB4.16-TdgClinicalTrial
APPGANTENERUMAB4.16-TdgClinicalTrial
APPCrenezumab4.16-TTD
APPPONEZUMAB4.16-TdgClinicalTrial
APPBapineuzumab4.16-TTD
APPREL-3,4-DICAFFEOYLQUINIC ACID2.77-DTC
APPDB050882.77-DrugBank
APPREL-3,5-DICAFFEOYLQUINIC ACID2.77-DTC
APPFERULIC ACID2.77-DTC
APPNSC-6494102.77-DTC
APP2-(4-NITROPHENYL)BENZO[D]THIAZOLE2.77-DTC
APPCHEMBL30395401.39-ChemblInteractions
APPACC-0011.39-TdgClinicalTrial
APPTramiprosate1.39-TTD
APPDB037541.39inhibitorDrugBank
APPCAPROSPINOL1.39-TdgClinicalTrial
APPSCYLLO-INOSITOL0.92-TdgClinicalTrial
APPELND0050.92-TTD
APPDB145170.69-DrugBank
APPDB145180.69-DrugBank
APPT-817MA0.69-TTD
APPDB048920.46-DrugBank
APPDB067820.46-DrugBank
APPPOSIPHEN0.46-TdgClinicalTrial
APPNIC5-150.46-TTD
APPPF-030840140.28-TTD
APPHYDROXYCHLOROQUINE0.23-NCI
APP2-CHLORO-ADENOSINETRIPHOSPHATE0.23-DTC
APPDB007460.18-DrugBank
APPCLIOQUINOL0.15-DTC
APPPARAROSANILINE0.13-DTC
APPPROPOFOL0.1-NCI
APPCONGO RED0.09-DTC
APPGENTIAN VIOLET0.08-DTC
APPDB027090.08-DrugBank
APPRESVERATROL0.08-DTC
APPCurcumin0.07-TTD
APPCURCUMIN0.07-DTC
APPDB091300.04inhibitorDrugBank
APPDAUNOMYCIN0.04-NCI
APPDB145330.03ligandDrugBank
APPDB015930.02cofactorDrugBank
APPDB09149-binderDrugBank
APPALZ-801--TTD
APPAffitope AD-01--TTD
APPAAB-003/PF-05236812--TTD
APPMER-5101--TTD
APPAAB-002--TTD
APPSystebryl--TTD
APPDB14548-ligandDrugBank
APPDWP-09031--TTD
APPALZT-OP1--TTD
APPFRM-0962--TTD
APPACI-24--TTD
APPCSP-1103--TTD
APPGSK933776A--TTD
APPAnti-N3pG-Abeta antibody--TTD
APPDB05938--DrugBank
APPBAF--NCI
APPMyo-inositol--TTD
APP11C-AZD-2184--TTD
APPDB09151-binderDrugBank
APPTAXANES--NCI
APPDB14487--DrugBank
APPSAR228810--TTD
APPEB-101--TTD
APPUB-311--TTD
APP11C-6-Me-BTA-1--TTD
APPV-950--TTD
APPPepticlere--TTD
APPDB02235--DrugBank
APPDB05846--DrugBank
APPAD-03--TTD
APPNRM8499--TdgClinicalTrial
APPDB09148-binderDrugBank
APPAD01--TdgClinicalTrial
APPAMB--NCI
APPDB01370--DrugBank
APPDB05150--DrugBank
APPHOMOTAURINE--TdgClinicalTrial
APPEXEBRYL-1--TdgClinicalTrial
APPBIIB037--TTD
APPNI-101--TTD
APPCAD-106--TTD
APPAN-1792--TTD
APPFlorbetapir F-18--TTD
APPNN-818--TTD
APPBIIB037--TdgClinicalTrial

Copyright @ Hunan Provincial Key Lab on Bioinformatics

School of Computer Science and Engineering, Central South University, Changsha, Hunan Province, P.R. China