You queried the gene CACNA1C in heart:

Symbol Synonyms map_location description
CACNA1C CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS 12p13.33 calcium voltage-gated channel subunit alpha1 C
  • Local network

The network contains the top 25 neighbors, and 80 gene pairs are found in total.

Download gene network data

  • Network analysis
  • Gene analysis
  • Local Network
  • Gene Ontology Enrichment
  • Disease/traits enrichment

The weight between CACNA1C and the top connected 25 genes.
Gene A Gene B Weight


Gene Ontology Enrichment Analysis (Biological Process Terms)

Enrichment Results for CACNA1C and its neighbors in heart network

GO IDGO nameFDR
GO:0070482response to oxygen levels2.94e-23
GO:0001525angiogenesis3.48e-23
GO:0050673epithelial cell proliferation3.52e-23
GO:0050678regulation of epithelial cell proliferation1.15e-22
GO:0048732gland development4.08e-21
GO:0036293response to decreased oxygen levels2.69e-20
GO:0030335positive regulation of cell migration5.50e-20
GO:0002009morphogenesis of an epithelium1.05e-19
GO:0070997neuron death1.16e-19
GO:2000147positive regulation of cell motility1.74e-19
GO:1901652response to peptide1.16e-18
GO:0043491protein kinase B signaling1.37e-18
GO:0001666response to hypoxia3.66e-18
GO:0002521leukocyte differentiation3.69e-18
GO:1903829positive regulation of cellular protein localization1.17e-17
GO:1901653cellular response to peptide1.32e-17
GO:0001655urogenital system development2.04e-17
GO:1901214regulation of neuron death2.61e-17
GO:0009314response to radiation2.71e-17
GO:0042110T cell activation3.69e-17
GO:0051896regulation of protein kinase B signaling4.70e-17
GO:0014706striated muscle tissue development2.22e-16
GO:0072001renal system development3.30e-16
GO:0060537muscle tissue development5.87e-16
GO:0042692muscle cell differentiation8.13e-16
GO:0042063gliogenesis8.43e-16
GO:0048145regulation of fibroblast proliferation1.12e-15
GO:0009612response to mechanical stimulus1.15e-15
GO:0048144fibroblast proliferation1.38e-15
GO:0018108peptidyl-tyrosine phosphorylation1.70e-15
GO:0009416response to light stimulus1.86e-15
GO:0018212peptidyl-tyrosine modification2.06e-15
GO:0006979response to oxidative stress2.07e-15
GO:0071900regulation of protein serine/threonine kinase activity5.87e-15
GO:0030258lipid modification8.17e-15
GO:0010001glial cell differentiation8.65e-15
GO:0072593reactive oxygen species metabolic process9.73e-15
GO:2000377regulation of reactive oxygen species metabolic process1.27e-14
GO:0048568embryonic organ development1.97e-14
GO:0048608reproductive structure development2.09e-14
GO:0061458reproductive system development2.48e-14
GO:0001822kidney development2.79e-14
GO:0050679positive regulation of epithelial cell proliferation5.82e-14
GO:0051897positive regulation of protein kinase B signaling6.62e-14
GO:0014065phosphatidylinositol 3-kinase signaling9.59e-14
GO:0097191extrinsic apoptotic signaling pathway1.15e-13
GO:0048015phosphatidylinositol-mediated signaling1.18e-13
GO:0046854phosphatidylinositol phosphorylation1.44e-13
GO:0048017inositol lipid-mediated signaling1.64e-13
GO:0007568aging1.97e-13


No enrichment is identified for this network.
  • Tissue-specific analysis
  • Gene Ontology
  • Human phenotype ontology
  • GWAS
  • Drug

Tissue-specific expression distribution of CACNA1C.


Gene ontology annotations for the queried gene based on Gene Ontology.

BP: Biological Process, MF: Molecular Function, CC: Cellular Component.
Gene GO_ID GO_term Category Evidence
CACNA1CGO:0002520immune system developmentBPIMP
CACNA1CGO:0005245voltage-gated calcium channel activityMFIBA,IDA,IMP
CACNA1CGO:0005515protein bindingMFIPI
CACNA1CGO:0005516calmodulin bindingMFIPI
CACNA1CGO:0005737cytoplasmCCIDA
CACNA1CGO:0005886plasma membraneCCIDA,TAS
CACNA1CGO:0005887integral component of plasma membraneCCISS
CACNA1CGO:0005891voltage-gated calcium channel complexCCIDA
CACNA1CGO:0006816calcium ion transportBPIBA
CACNA1CGO:0007204positive regulation of cytosolic calcium ion concentrationBPIDA
CACNA1CGO:0007507heart developmentBPIMP
CACNA1CGO:0008331high voltage-gated calcium channel activityMFIBA,IDA,TAS
CACNA1CGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionBPISS,TAS
CACNA1CGO:0014069postsynaptic densityCCIDA
CACNA1CGO:0016021integral component of membraneCCIDA
CACNA1CGO:0016032viral processBPIEA
CACNA1CGO:0030018Z discCCISS
CACNA1CGO:0030425dendriteCCIEA
CACNA1CGO:0035115embryonic forelimb morphogenesisBPIMP
CACNA1CGO:0035585calcium-mediated signaling using extracellular calcium sourceBPTAS
CACNA1CGO:0043010camera-type eye developmentBPIMP
CACNA1CGO:0043204perikaryonCCIEA
CACNA1CGO:0045762positive regulation of adenylate cyclase activityBPISS
CACNA1CGO:0046872metal ion bindingMFIEA
CACNA1CGO:0050796regulation of insulin secretionBPTAS
CACNA1CGO:0051393alpha-actinin bindingMFIPI
CACNA1CGO:0060402calcium ion transport into cytosolBPISS,TAS
CACNA1CGO:0061337cardiac conductionBPIMP,TAS
CACNA1CGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelBPIDA
CACNA1CGO:0070509calcium ion importBPIBA
CACNA1CGO:0070588calcium ion transmembrane transportBPIDA,IMP
CACNA1CGO:0086002cardiac muscle cell action potential involved in contractionBPIMP
CACNA1CGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialMFIMP,IMP
CACNA1CGO:0086012membrane depolarization during cardiac muscle cell action potentialBPIMP
CACNA1CGO:0086045membrane depolarization during AV node cell action potentialBPIMP
CACNA1CGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialMFIMP
CACNA1CGO:0086064cell communication by electrical coupling involved in cardiac conductionBPTAS
CACNA1CGO:0086091regulation of heart rate by cardiac conductionBPIMP
CACNA1CGO:0098839postsynaptic density membraneCCIEA
CACNA1CGO:0098911regulation of ventricular cardiac muscle cell action potentialBPIMP
CACNA1CGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialBPIMP
CACNA1CGO:1990454L-type voltage-gated calcium channel complexCCIDA

Associated human phenotype annotations for the queried gene based on Human Phenotype Ontology(2019).

Gene HPO-ID HPO-Name Disease
CACNA1CHP:0001695Cardiac arrestBrugada syndrome 9
CACNA1CHP:0004755Supraventricular tachycardiaBrugada syndrome 9
CACNA1CHP:0004751Paroxysmal ventricular tachycardiaBrugada syndrome 9
CACNA1CHP:0011704Sick sinus syndromeBrugada syndrome 9
CACNA1CHP:0001663Ventricular fibrillationBrugada syndrome 9
CACNA1CHP:0011715Trifascicular blockBrugada syndrome 9
CACNA1CHP:0011712Right bundle branch blockBrugada syndrome 9
CACNA1CHP:0001279SyncopeBrugada syndrome 9
CACNA1CHP:0011705First degree atrioventricular blockBrugada syndrome 9
CACNA1CHP:0012251ST segment elevationBrugada syndrome 9
CACNA1CHP:0002719Recurrent infectionsTimothy syndrome
CACNA1CHP:0000219Thin upper lip vermilionTimothy syndrome
CACNA1CHP:0001699Sudden deathTimothy syndrome
CACNA1CHP:0001629Ventricular septal defectTimothy syndrome
CACNA1CHP:0001643Patent ductus arteriosusTimothy syndrome
CACNA1CHP:0012387BronchitisTimothy syndrome
CACNA1CHP:0001662BradycardiaTimothy syndrome
CACNA1CHP:0001640CardiomegalyTimothy syndrome
CACNA1CHP:0000006Autosomal dominant inheritanceTimothy syndrome
CACNA1CHP:0001636Tetralogy of FallotTimothy syndrome
CACNA1CHP:0001159SyndactylyTimothy syndrome
CACNA1CHP:0001943HypoglycemiaTimothy syndrome
CACNA1CHP:0002901HypocalcemiaTimothy syndrome
CACNA1CHP:0001249Intellectual disabilityTimothy syndrome
CACNA1CHP:0000717AutismTimothy syndrome
CACNA1CHP:0001655Patent foramen ovaleTimothy syndrome
CACNA1CHP:0000691MicrodontiaTimothy syndrome
CACNA1CHP:0000821HypothyroidismTimothy syndrome
CACNA1CHP:0001250SeizureTimothy syndrome
CACNA1CHP:0001290Generalized hypotoniaTimothy syndrome
CACNA1CHP:0012725Cutaneous syndactylyTimothy syndrome
CACNA1CHP:0002090PneumoniaTimothy syndrome
CACNA1CHP:0001657Prolonged QT intervalTimothy syndrome
CACNA1CHP:0001263Global developmental delayTimothy syndrome
CACNA1CHP:0005280Depressed nasal bridgeTimothy syndrome
CACNA1CHP:0000311Round faceTimothy syndrome
CACNA1CHP:0012332Abnormal autonomic nervous system physiologyLong QT syndrome 15
CACNA1CHP:0001197Abnormality of prenatal development or birthLong QT syndrome 15
CACNA1CHP:0005135Abnormal T-waveLong QT syndrome 15
CACNA1CHP:0001688Sinus bradycardiaLong QT syndrome 15
CACNA1CHP:0500018Abnormal cardiac exercise stress testLong QT syndrome 15
CACNA1CHP:0001250SeizureLong QT syndrome 15
CACNA1CHP:0001279SyncopeLong QT syndrome 15
CACNA1CHP:0002900HypokalemiaLong QT syndrome 15
CACNA1CHP:0001664Torsade de pointesLong QT syndrome 15
CACNA1CHP:0001645Sudden cardiac deathLong QT syndrome 15
CACNA1CHP:0005184Prolonged QTc intervalLong QT syndrome 15
CACNA1CHP:0004308Ventricular arrhythmiaBrugada syndrome 3
CACNA1CHP:0000006Autosomal dominant inheritanceBrugada syndrome 3
CACNA1CHP:0012232Shortened QT intervalBrugada syndrome 3
CACNA1CHP:0001279SyncopeBrugada syndrome 3
CACNA1CHP:0012272J waveBrugada syndrome 3
CACNA1CHP:0001645Sudden cardiac deathBrugada syndrome 3
CACNA1CHP:0005110Atrial fibrillationBrugada syndrome 3

Associated disease/traits for the queried gene based on GWAS Catalog(2020-11-20).


Gene Diseases/traits SNP p-value PMID
CACNA1CAutism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)rs10067375e-0923453885

Associated drugs for the queried gene based on DGIdb (2021-May).

'-': indicating missing value not available in DGIdb.

Gene DrugName Score Type Source
CACNA1CDB092273.92antagonistDrugBank
CACNA1CDB092361.96antagonistDrugBank
CACNA1CDB067511.47inhibitorDrugBank
CACNA1CDB092310.98antagonistDrugBank
CACNA1Critodrine0.98-PharmGKB
CACNA1CDB092380.98blockerDrugBank
CACNA1C3811188690.98blockerGuideToPharmacology
CACNA1C1781012160.78inhibitorGuideToPharmacology
CACNA1CISRADIPINE0.78-TdgClinicalTrial
CACNA1CISRADIPINE0.78-TEND
CACNA1CCHEMBL16480.78blockerChemblInteractions
CACNA1CDB002700.78inhibitorDrugBank
CACNA1CDB092370.73antagonistDrugBank
CACNA1CDB092350.65-DrugBank
CACNA1CCHEMBL12371320.65blockerChemblInteractions
CACNA1CCLEVIDIPINE0.65-TdgClinicalTrial
CACNA1CDB049200.65-DrugBank
CACNA1CDB139610.59inhibitorDrugBank
CACNA1CDB008250.59antagonistDrugBank
CACNA1CIBUTILIDE0.53-TdgClinicalTrial
CACNA1CIBUTILIDE0.53-TEND
CACNA1CDB003080.53activatorDrugBank
CACNA1CDB003930.51inhibitorDrugBank
CACNA1Cnimodipine0.51-PharmGKB
CACNA1CCHEMBL14280.51blockerChemblInteractions
CACNA1CDB092320.49antagonistDrugBank
CACNA1CDB067120.42inhibitorDrugBank
CACNA1CDB002430.41inhibitorDrugBank
CACNA1C1356507220.4inhibitorGuideToPharmacology
CACNA1CCHEMBL17260.4blockerChemblInteractions
CACNA1CDB004010.4inhibitorDrugBank
CACNA1CDB137460.39blockerDrugBank
CACNA1CDB090890.37inhibitorDrugBank
CACNA1CDB003810.29inhibitorDrugBank
CACNA1CAMLODIPINE0.29-TdgClinicalTrial
CACNA1CFELODIPINE0.28-TdgClinicalTrial
CACNA1CCHEMBL14800.28blockerChemblInteractions
CACNA1CDB122780.28antagonistDrugBank
CACNA1CDB010230.28inhibitorDrugBank
CACNA1CCHEMBL12008050.24blockerChemblInteractions
CACNA1C538010580.24blockerGuideToPharmacology
CACNA1CDB003430.24blockerDrugBank
CACNA1CDB013880.24inhibitorDrugBank
CACNA1C1356501850.24blockerGuideToPharmacology
CACNA1CCHEMBL12009840.24blockerChemblInteractions
CACNA1CDB010540.23inhibitorDrugBank
CACNA1CDB116330.22inhibitorDrugBank
CACNA1CDB006610.2inhibitorDrugBank
CACNA1CCHEMBL16970.2blockerChemblInteractions
CACNA1CVERAPAMIL0.2-TdgClinicalTrial
CACNA1C1356513050.2blockerGuideToPharmacology
CACNA1CVERAPAMIL0.2-TEND
CACNA1CCHEMBL12004020.2blockerChemblInteractions
CACNA1Cverapamil0.2-PharmGKB
CACNA1CDB011180.18inhibitorDrugBank
CACNA1CDB005680.17inhibitorDrugBank
CACNA1CCHEMBL35451690.16blockerChemblInteractions
CACNA1CDB092290.16antagonistDrugBank
CACNA1CCHEMBL12800.14blockerChemblInteractions
CACNA1CNICARDIPINE0.14-TdgClinicalTrial
CACNA1CDB006220.14inhibitorDrugBank
CACNA1CNICARDIPINE0.14-TEND
CACNA1CCHEMBL299190.12blockerChemblInteractions
CACNA1CCHEMBL12003260.11blockerChemblInteractions
CACNA1CDB011100.1inhibitorDrugBank
CACNA1CDB011150.09inhibitorDrugBank
CACNA1CCHEMBL1930.09blockerChemblInteractions
CACNA1CDB013730.09ligandDrugBank
CACNA1CDB048550.07inhibitorDrugBank
CACNA1Ccitalopram0.06-PharmGKB
CACNA1Catenolol0.06-PharmGKB
CACNA1CCHEMBL12017290.06blockerChemblInteractions
CACNA1CDB002520.05inhibitorDrugBank
CACNA1CCHEMBL10590.04modulatorChemblInteractions
CACNA1CCHEMBL16285020.04modulatorChemblInteractions
CACNA1CCHEMBL5934300.04modulatorChemblInteractions
CACNA1CDB002730.04antagonistDrugBank
CACNA1CCHEMBL21038360.04modulatorChemblInteractions
CACNA1CCHEMBL12003820.04blockerChemblInteractions
CACNA1CCHEMBL9400.03modulatorChemblInteractions
CACNA1CDB008980.03-DrugBank
CACNA1Ccelecoxib0.03-PharmGKB
CACNA1Cethanol0.03-PharmGKB
CACNA1Chaloperidol0.02-PharmGKB
CACNA1CDB00653-inhibitor,blockerDrugBank
CACNA1CARC029--TTD
CACNA1C53801055-blockerGuideToPharmacology
CACNA1Cvalproic acid--PharmGKB
CACNA1Ccalcium channel blockers--PharmGKB
CACNA1C178100970-blockerGuideToPharmacology
CACNA1C178100888-activatorGuideToPharmacology
CACNA1CRAUWOLFIA SERPENTINA ROOT--TTD
CACNA1CARVERAPAMIL--TdgClinicalTrial
CACNA1CMEM 1003--TdgClinicalTrial
CACNA1C178101135-activatorGuideToPharmacology
CACNA1C135651166-inhibitorGuideToPharmacology

Copyright @ Hunan Provincial Key Lab on Bioinformatics

School of Computer Science and Engineering, Central South University, Changsha, Hunan Province, P.R. China