You queried the gene RXRA in brain:

Symbol Synonyms map_location description
RXRA NR2B1 9q34.2 retinoid X receptor alpha
  • Local network

The network contains the top 25 neighbors, and 229 gene pairs are found in total.

Download gene network data

  • Network analysis
  • Gene analysis
  • Local Network
  • Gene Ontology Enrichment
  • Disease/traits enrichment

The weight between RXRA and the top connected 25 genes.
Gene A Gene B Weight


Gene Ontology Enrichment Analysis (Biological Process Terms)

Enrichment Results for RXRA and its neighbors in brain network

GO IDGO nameFDR
GO:0048732gland development4.39e-76
GO:0046677response to antibiotic5.78e-60
GO:0007568aging1.77e-56
GO:1901652response to peptide1.42e-55
GO:0031667response to nutrient levels4.31e-55
GO:0070482response to oxygen levels2.51e-49
GO:0048608reproductive structure development9.65e-48
GO:0061458reproductive system development2.19e-47
GO:0001525angiogenesis4.96e-47
GO:0043434response to peptide hormone4.74e-45
GO:0097305response to alcohol9.19e-45
GO:0036293response to decreased oxygen levels3.25e-44
GO:0001666response to hypoxia6.87e-44
GO:0050673epithelial cell proliferation1.29e-43
GO:0048568embryonic organ development1.03e-42
GO:0007584response to nutrient1.54e-42
GO:1901653cellular response to peptide1.98e-42
GO:0001101response to acid chemical8.90e-42
GO:0003007heart morphogenesis1.48e-39
GO:0050678regulation of epithelial cell proliferation8.01e-39
GO:0035690cellular response to drug9.09e-39
GO:0071900regulation of protein serine/threonine kinase activity1.92e-37
GO:0048871multicellular organismal homeostasis4.26e-37
GO:0019216regulation of lipid metabolic process4.96e-37
GO:0002009morphogenesis of an epithelium6.25e-37
GO:0045471response to ethanol2.12e-36
GO:0030335positive regulation of cell migration2.51e-36
GO:0033002muscle cell proliferation2.90e-36
GO:0001667ameboidal-type cell migration8.98e-36
GO:0001655urogenital system development1.09e-35
GO:2000147positive regulation of cell motility1.93e-35
GO:0035270endocrine system development3.29e-35
GO:0060562epithelial tube morphogenesis3.71e-35
GO:0071375cellular response to peptide hormone stimulus1.25e-34
GO:0072001renal system development5.65e-34
GO:0003013circulatory system process1.47e-33
GO:0002521leukocyte differentiation2.41e-33
GO:0048545response to steroid hormone2.48e-33
GO:0070997neuron death3.55e-33
GO:0006979response to oxidative stress1.39e-32
GO:2001233regulation of apoptotic signaling pathway1.16e-31
GO:0032147activation of protein kinase activity1.87e-31
GO:0001822kidney development1.93e-31
GO:1901342regulation of vasculature development2.39e-31
GO:0008015blood circulation2.59e-31
GO:0097191extrinsic apoptotic signaling pathway5.87e-31
GO:0060485mesenchyme development1.12e-30
GO:0048762mesenchymal cell differentiation2.67e-30
GO:0003205cardiac chamber development4.18e-30
GO:0000302response to reactive oxygen species4.41e-30


No enrichment is identified for this network.
  • Tissue-specific analysis
  • Gene Ontology
  • Human phenotype ontology
  • GWAS
  • Drug

Tissue-specific expression distribution of RXRA.


Gene ontology annotations for the queried gene based on Gene Ontology.

BP: Biological Process, MF: Molecular Function, CC: Cellular Component.
Gene GO_ID GO_term Category Evidence
RXRAGO:0000122negative regulation of transcription by RNA polymerase IIBPIBA,IDA
RXRAGO:0000785chromatinCCIDA,ISA
RXRAGO:0000976transcription regulatory region sequence-specific DNA bindingMFIDA
RXRAGO:0000977RNA polymerase II transcription regulatory region sequence-specific DNA bindingMFIDA
RXRAGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingMFIBA,IDA
RXRAGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificMFISA
RXRAGO:0001972retinoic acid bindingMFIDA
RXRAGO:0003690double-stranded DNA bindingMFIMP
RXRAGO:0003700DNA-binding transcription factor activityMFIDA
RXRAGO:0003707steroid hormone receptor activityMFIEA
RXRAGO:0004879nuclear receptor activityMFIBA,IDA,TAS
RXRAGO:0005515protein bindingMFIPI
RXRAGO:0005634nucleusCCIDA
RXRAGO:0005654nucleoplasmCCTAS
RXRAGO:0005739mitochondrionCCIEA
RXRAGO:0006357regulation of transcription by RNA polymerase IIBPIBA
RXRAGO:0006367transcription initiation from RNA polymerase II promoterBPTAS
RXRAGO:0008203cholesterol metabolic processBPTAS
RXRAGO:0008270zinc ion bindingMFIDA
RXRAGO:0015721bile acid and bile salt transportBPTAS
RXRAGO:0016922nuclear receptor bindingMFIPI
RXRAGO:0019048modulation by virus of host processBPIDA
RXRAGO:0019216regulation of lipid metabolic processBPTAS
RXRAGO:0019899enzyme bindingMFIPI
RXRAGO:0030154cell differentiationBPIBA
RXRAGO:0032526response to retinoic acidBPIBA,IMP
RXRAGO:0035357peroxisome proliferator activated receptor signaling pathwayBPIDA
RXRAGO:0042277peptide bindingMFIDA
RXRAGO:0042802identical protein bindingMFIPI
RXRAGO:0042809vitamin D receptor bindingMFIPI
RXRAGO:0043235receptor complexCCIDA
RXRAGO:0043401steroid hormone mediated signaling pathwayBPIEA
RXRAGO:0043565sequence-specific DNA bindingMFIDA
RXRAGO:0044323retinoic acid-responsive element bindingMFIBA,IDA
RXRAGO:0045893positive regulation of transcription, DNA-templatedBPIDA
RXRAGO:0045944positive regulation of transcription by RNA polymerase IIBPIBA,IDA
RXRAGO:0048384retinoic acid receptor signaling pathwayBPIBA,IMP
RXRAGO:0048856anatomical structure developmentBPIBA
RXRAGO:0050692DNA binding domain bindingMFIDA
RXRAGO:0050693LBD domain bindingMFIDA
RXRAGO:0070644vitamin D response element bindingMFIDA
RXRAGO:0090575RNA polymerase II transcription regulator complexCCIBA,IDA
RXRAGO:1990837sequence-specific double-stranded DNA bindingMFIDA

Your queried gene is not associated with any phenotype in human phenotype ontology.

Associated disease/traits for the queried gene based on GWAS Catalog(2020-11-20).


Gene Diseases/traits SNP p-value PMID
RXRACentral corneal thicknessrs48418991e-1329760442
RXRACentral corneal thicknessrs31185159e-1128171582
RXRACentral corneal thicknessrs31185206e-0930894546
RXRACentral corneal thicknessrs15364782e-0828171582

Associated drugs for the queried gene based on DGIdb (2021-May).

'-': indicating missing value not available in DGIdb.

Gene DrugName Score Type Source
RXRA9Z-RETINOIC ACID1.96-DTC
RXRAPHYTANIC ACID1.31-DTC
RXRADB003071.24agonistDrugBank
RXRACHEMBL10231.24agonistChemblInteractions
RXRA1356505201.24agonistGuideToPharmacology
RXRABEXAROTENE1.24-TdgClinicalTrial
RXRABEXAROTENE1.24-TEND
RXRABEXAROTENE1.24activatorTALC
RXRABexarotene1.24-TTD
RXRABEXAROTENE1.24-DTC
RXRADB005230.87agonistDrugBank
RXRAALITRETINOIN0.87-TEND
RXRA1356514180.87agonistGuideToPharmacology
RXRAAlitretinoin0.87-TTD
RXRAALITRETINOIN0.87-DTC
RXRACHEMBL7050.87agonistChemblInteractions
RXRAMETRIBUZIN0.65-DTC
RXRADEMETON S0.65-DTC
RXRADB086010.65-DrugBank
RXRA2-PHENOXYETHANOL0.65-DTC
RXRADB080630.65-DrugBank
RXRACHLORHEXIDINE DIACETATE0.65-DTC
RXRAOCTADECYLAMINE0.65-DTC
RXRADB002100.52agonistDrugBank
RXRAADAPALENE0.52-TdgClinicalTrial
RXRAADAPALENE0.52-TEND
RXRADB009260.47agonistDrugBank
RXRACHEMBL4640.47agonistChemblInteractions
RXRADB014360.44-DrugBank
RXRADB084020.44-DrugBank
RXRAQUINOXYFEN0.33-DTC
RXRAANTHRAQUINONE0.33-DTC
RXRABROMETHALIN0.33-DTC
RXRAMESOTRIONE0.33-DTC
RXRADB075570.33-DrugBank
RXRADIFLUBENZURON0.33-DTC
RXRACHEMBL17160910.33modulatorChemblInteractions
RXRABIPHENYL0.33-DTC
RXRADB007490.33-DrugBank
RXRAFERBAM0.33-DTC
RXRADOCONEXENT0.3-DTC
RXRADB037560.3activatorDrugBank
RXRADB042240.26-DrugBank
RXRAHONOKIOL0.26-DTC
RXRAAZINPHOS-ETHYL0.22-DTC
RXRADB059560.22-DrugBank
RXRAFLUDIOXONIL0.22-DTC
RXRACHEMBL751330.22agonistChemblInteractions
RXRAABAMECTIN0.22-DTC
RXRADIMETHYLFORMAMIDE0.22-DTC
RXRADB013930.19agonistDrugBank
RXRAPROPARGITE0.16-DTC
RXRABROMOXYNIL0.16-DTC
RXRACHLORFENAPYR0.16-DTC
RXRATRIBUTYLCHLOROSTANNANE0.16-DTC
RXRA2-BROMO-HEXADECANOIC ACID0.16-DTC
RXRADB004590.15agonistDrugBank
RXRACHEMBL11310.15agonistChemblInteractions
RXRADB027460.13-DrugBank
RXRATRIBUTYLTIN-OXIDE0.13-DTC
RXRACLOROPHENE0.13-DTC
RXRADIBUTYLDICHLOROSTANNANE0.13-DTC
RXRAPYRACLOSTROBIN0.13-DTC
RXRADB078630.13-DrugBank
RXRADIFENOCONAZOLE0.13-DTC
RXRA2-PHENYLPHENOL0.13-DTC
RXRATRIPHENYLSTANNANOL0.13-DTC
RXRABUTYLATED HYDROXYTOLUENE0.11-DTC
RXRAIMIPRAMINE HYDROCHLORIDE0.11-DTC
RXRACHEMBL1465060.11modulatorChemblInteractions
RXRATRICLOCARBAN0.09-DTC
RXRASAQUINAVIR MESYLATE0.09-DTC
RXRA1781020780.09antagonistGuideToPharmacology
RXRASULINDAC0.09-DTC
RXRADB045570.08-DrugBank
RXRASTANOLONE0.08-DTC
RXRATRICLOSAN0.07-DTC
RXRABENZO(K)FLUORANTHENE0.07-DTC
RXRA7,12-DIMETHYL-BENZO[A]ANTHRACENE0.06-DTC
RXRAROTENONE0.05-DTC
RXRACHLOROTHALONIL0.05-DTC
RXRARO-1374100.05-DTC
RXRADB001320.04-DrugBank
RXRADICHLOROPHEN0.04-DTC
RXRADB007550.04-DrugBank
RXRADACTINOMYCIN0.04-DTC
RXRAT0913170.04-DTC
RXRABENZO[D]ISOTHIAZOL-3-ONE0.04-DTC
RXRADB004120.04-DrugBank
RXRAAFIMOXIFENE0.04-DTC
RXRATRETINOIN0.04-DTC
RXRABENZETHONIUM CHLORIDE0.04-DTC
RXRATHIRAM0.03-DTC
RXRATHIOMERSAL0.03-DTC
RXRARALOXIFENE HYDROCHLORIDE0.03-DTC
RXRABITHIONOL0.03-DTC
RXRANICLOSAMIDE0.02-DTC
RXRADAUNORUBICIN HYDROCHLORIDE0.02-DTC
RXRATESTOSTERONE0.02-DTC
RXRAGW76470.02-DTC
RXRAdocetaxel0.02-PharmGKB
RXRAHOMIDIUM BROMIDE0.02-DTC
RXRAPIMOZIDE0.02-DTC
RXRADOXORUBICIN HYDROCHLORIDE0.02-DTC
RXRAGENISTEIN0.01-DTC
RXRAPROGESTERONE0.01-DTC
RXRA135650518-antagonistGuideToPharmacology
RXRA249565759-antagonistGuideToPharmacology
RXRA135649905-agonistGuideToPharmacology
RXRA310264686-antagonistGuideToPharmacology
RXRAR-ETODOLAC--TdgClinicalTrial
RXRA135650586-agonistGuideToPharmacology
RXRA310264685-agonistGuideToPharmacology
RXRA381118896-agonistGuideToPharmacology
RXRA381745028-antagonistGuideToPharmacology
RXRAALITRETIONINE--TdgClinicalTrial
RXRA135650517-agonistGuideToPharmacology
RXRA135650786-antagonistGuideToPharmacology

Copyright @ Hunan Provincial Key Lab on Bioinformatics

School of Computer Science and Engineering, Central South University, Changsha, Hunan Province, P.R. China